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We randomized 31 children with a 1st afebrile unprovoked seizure to receive carbamazepine(CBZ)or no medication for 1 year or until the time of a 2nd seizure.All seizures had a focal onset or were generalized tonic- clonic.Overall,2/14 randomized to CBZ and 9/17 with no medication had a recurrent afebrile seizure.Compliance with CBZ was excellent in 12/14,but noncompliance may have contributed to 1 of the recurrences with CBZ.Four discontinued CBZ because of side effects.Two additional children taking CBZ had a febrile seizure.Thus,only 6/14 taking CBZ had a year completely seizure-free with no unacceptable medication side effects.Of those taking no medication,2 had a febrile recurrence,and 7/17 had a year completely- seizure free.Side effects and febrile recurrences may limit the value of CBZ for some children,although CBZ appears to reduce significantly recurrences after a 1st afebrile seizure. |
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carbamazepine
seizure,children
seizure,prognosis in childhood
seizure,treatment of
seizure,treatment of,first
seizure,treatment of,monotherapy
treatment of neurologic disorder
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