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The modern fluoroquinolone antibiotics such as norfloxacin,ciprofloxacin, and ofloxacin are known to induce central nervous system(CNS)side effects. Next to gastrointestinal effects,CNS symptoms such as dizziness,headache, restlessness,tremor,and/or insomnia are the most commonly reported toxicities,occurring in 0.1%to 4%of patients.In addition,other neuropsychiatric effects like seizures,psychosis,confusion,agitation,and asthenia may be infrequently associated with use of these agents.All are reversible after drug withdrawal and are generally not dose dependent.To our knowledge,based upon a review of the literature,the following case represents the first reported occurrence of eosinophilic meningitis associated with ciprofloxacin administration. |
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