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There are two types of heparin-induced thrombocytopenia.Type I is more common,has an early onset,and is mild,transient,and benign.Type I is due to direct heparin-induced platelet aggregation and is rarely associated with thromboembolic sequela.Type II is infrequent,has a late onset,and is more severe.Type II is due to an immune-mediated platelet aggregation caused by IgG and IgM that becomes bound to platelets.In Type II the antibody titers decline over several months;however,early reexposure can result in a catastrophic secondary immune response.Frequently,Type II is associated with life-or limb-threatening thromboembolic complications (white clots),including stroke. |
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