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Over 2 years,104 patients underwent clinical evaluation and laboratory screening for the presence of abnormal anticardiolipin antibodies to determine the profile of laboratory and clinical findings in patients with stroke and other neurologic disorders.Seven with incomplete or ambiguous data were excluded;of the remaining 97 patients,31 were>/=65 years old. Nine patients suffered systemic lupus erythematosus,45 suffered brain ischemia,and 43 suffered other nonischemic neurologic disorders.Cardiac arrhythmia,myocardial infarction,and cardiac valvulopathy were grounds for exclusion.The presence of anticardiolipin antibodies was not influenced by age.In the 88 patients without lupus,anticardiolipin antibodies were significantly more common in the group suffering brain ischemia than in the group with nonischemic neurologic disorders(29%vs 5%,p<0.01,x2 test). These controlled data demonstrate an association between the presence of circulating anticardiolipin antibodies with stroke,but not with other neurologic conditions. |
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