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Effects of Botulinum Toxin Injections on Speech in Adductor Spasmodic Dysphonia
Neurol 38:1220-1225, Ludlow,C.L.,et al, 1988
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Article Abstract
Adductor spasmodic dysphonia involves an overadduction of the vocal folds during speech causing uncontrolled voice and pitch breaks and slow, effortful speech.The disorder is resistant to speech therapy and often recurs following initial benefit from unilateral recurrent laryngeal nerve resection.Botulinum toxin injections into multiple sites of the thyroarytenoid muscle on one side were performed in 16 patients.Speech was recorded prior to injection and three times post injection.Symptoms were measured by two examiners from speech spectrograms without knowledge of speaker identity or recording session.Significant(p=0.03)reductions in pitch and voice breaks,phonatory aperiodicity,and sentence time occurred only when injections resulted in unilateral vocal fold paralysis.Symptoms returned with the restoration of vocal fold movement,3 months later. Reduction in speed of swallowing without aspiration was reported in 80%of cases.Although speech volume was reduced,there were no instances of aphonia.
Related Tags
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botulinum toxin
dystonia
dystonia,focal
dystonia,laryngeal
dystonia,treatment of
spastic dysphonia
treatment of neurologic disorder
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