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There is a paucity of reports of classic amyotrophic lateral sclerosis (ALS)developing in survivors of paralytic poliomyelitis.We describe a patient with classic ALS and an antecedent paralytic disease thought to have been poliomyelitis from which she recovered completely.If the paucity of ALS preceded by true poliomyelitis is not merely a matter of underreporting,antecedent paralytic poliomyelitis may have a protective role against the development of ALS.This has implications relevant to pathogenesis and to projected secular trends of ALS incidence since the introduction of poliomyelitis vaccines.There is a need to establish the incidence of cases of classic ALS in patients with antecedent poliomyelitis. |
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