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We reviewed the clinical and neuropathologic findings in 21 patients who had seizures after orthotopic liver transplants.Tonic-clonic seizures were the most common seizure type.Six patients developed status epilepticus.In 9 patients,seizures occurred within 1 week following transplantation.We found CNS lesions that were probably responsible for the occurrence of seizures in most patients;some had more than 1 finding.Neuropathologic examination revealed ischemic or hemorrhagic strokes in 18 patients, central pontine myelinolysis in 5,and CNS infections in 5.Multiple metabolic abnormalities were a contributing factor to the onset of seizures in some patients. |
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