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High-Dose Intravenous Immunoglobulin in the Treatment of Demyelinating Neuropathy with Monoclonal Gammopathy Neurol 40:212-214, 327-3281990., Cook,D.,et al, 1990 See this aricle in Pubmed Article Abstract We treated 2 patients with IgM monoclonal paraproteinemic demyelinating peripheral neuropathy(PPN)with monthly intravenous human immunoglobulin. Both patients had a steadily progressive course in spite of steroid and other immunosuppressive therapy for 3 years before starting the immunoglobulin therapy.Both had a rapid clinical improvement noticeable 5 to 10 days after the 1st immunoglobulin infusion lasting on the average of 3 to 6 weeks.Retreatment caused improvement after each consecutive infusion.There were no significant adverse side effects.High-dose IV human immunoglobulin can be a useful therapy in the treatment of PPN and warrants a large-scale controlled therapeutic trial.

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(click to filter results - removes previous filter) gammaglobulin therapy,intravenous monoclonal gammopathy neuropathy neuropathy,peripheral neuropathy,peripheral,treatment paraproteinemia polyneuropathy treatment of neurologic disorder

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