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A Comparison of Effects of Controlled-Release Levodopa (Madopar CR) with Levodopa in Late Parkinson's Disease JNNP 53:220-223, MacMahon,D.G.,et al, 1990 See this aricle in Pubmed Article Abstract Individually 25 out of 37 had an increase in"on"time and 19 out of 37 experienced a decrease in"off"time.Thus Madopar CR was found to be beneficial in a significant proportion of patients experiencing fluctuations in response to conventional levodopa.

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