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Intracerebral Hemorrhage Related to Cerebral Amyloid Angiopathy and t-PA Treatment Ann Neurol 29:210-213, Pendlebury,W.W.,et al, 1991 See this aricle in Pubmed Article Abstract Tissue plasminogen activator(t-PA)has been approved as thrombolytic therapy for the treatment of acute myocardial infarction,but this agent can cause serious bleeding complications including intracerebral hemorrhages.Mechanisms underlying the development of these hemorrhages have not been clarified.We report a patient who developed two intracerebral hemorrhages shortly after receiving t-PA for the treatment of an acute myocardial infarction,and who was found to have cerebral amyloid angiopathy at autopsy.Staining of cortical sections with Conge red and an antibody directed against beta amyloid protein(A4 peptide)disclosed specific involvement of most of the subarachnoid and superficial cortical vessels in the region of the two hemorrhages.Based on the findings in this patient and in 6 additional patients reported recently,it is likely that cerebral amyloid angiopathy plays a pathogenic role in some intracerebral hemorrhages associated with administration of t-PA.The cautious use of t- PA with heparin in patients who are elderly or demented may be advisable.

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(click to filter results - removes previous filter) amyloid angiopathy,cerebral CAT scan CAT scan,abnormal fibrinolytic agents fibrinolytic agents,complications intracerebral hemorrhage intracerebral hemorrhage,multiple tissue plasminogen activator,intravenous

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