|
|
|
|
Treatment of 9 patients with Wilson's disease was prospectively studied with evoked potentials and magnetic resonance imaging(MRI).Oral penicillamine therapy led to a decrease in auditory brainstem(ABP)and somatosensory(SEP)conduction times and in 6 and 4 neurologically symptomatic patients,respectively.ABP and SEP were normal in 3 other symptom-free patients.Quantified indices of brain atrophy were unaffected by treatment.ABP and SEP may reveal a reversible component of the disease that cannot be detected by MRI,and may be a more sensitive measure of treatment efficacy. |
|