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A Follow-up Study of Intractable Seizures in Childhood Ann Neurol 28:699-705, Huttenlocher,P.R.&Hapke,R.J., 1990 See this aricle in Pubmed Article Abstract One hundred forty-five children with seizures that were refractory to medical therapy for at least 2 years were followed 5 to 20 years after onset.The majority of children with uncontrollable seizures(61%)were mentally retarded,and most of these(73%)had onset of seizures at younger than 2 years of age.Age of onset was significantly later(mean 5.0+/=0.5 yr[SEM])in the group of children with borderzone to normal intelligence. Follow-up data showed remission of seizures in a significant proportion of children with borderline or normal intelligence,with a linear decrease of the percentage with persistent seizures at a rate of about 4%per year. Remission of seizures was much less frequent(1.5%/yr)in the group with mental retardation.Seizure type had some effects on outcome.Children with focal atrophic brain lesions did no worse than those without definable pathology on brain-imaging studies.

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