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Pneumocystis Carinii Pneumonia in Patients with Primary Brain Tumors
Arch Neurol 48:406-409, Henson,J.W.,et al, 1991
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Article Abstract
All histologically documented episodes of Pneumocystis carinii pneumonia in adult patients with primary brain tumors treated at Memorial Sloan- Kettering Cancer Center,New York,NY,since 1981,were retrospectively reviewed.Pneumocystis carinii pneumonia was histologically documented 11 times in 10 patients.During the same 8-year interval,approximately 587 adults were seen at the center for a brain tumor,90%of whom received ongoing therapy.Therefore,in at least 1.7%(10/587)of our patients with brain tumors,P carinii pneumonia developed.The median duration of dexamethasone therapy at the onset of P carinii pneumonia symptoms was 2. 75 months.Symptoms began during tapering of steroid therapy in eight episodes.Bronchoscopy was diagnostic in the eight cases in which it was performed.Four episodes(40%)were fatal.Trimethoprim-sulfamethoxazole prophylaxis may be indicated in some patients with brain tumors,especially during tapering of steroid therapy.
 
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immunosuppression
immunosuppressive agents
mortality
neoplasm,primary intracerebral
neoplasm,primary of CNS
opportunistic infection
pneumocystis carinii
prognosis
pulmonary infiltrates
steroid therapy,CNS treatment and complications with

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