Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Progressive Language Disorder Due to Lobar Atrophy
Ann Neurol 31:174-183, Snowden,J.S.,et al, 1992
See this aricle in Pubmed

Article Abstract
Sixteen patients with progressive language disorder have been studied longitudinally.Anomia was a prominent presenting characteristic and mutism ultimately occurred.Patients,however,were clinically heterogenous.Some exhibited nonfluent,agrammatic features,whereas others demonstrated a fluent aphasia,with profound loss of word meaning.Although language disorder remained the sole symptom in a minority of patients,in others an associative agnosia or personality and behavioral changes,or both,emerged. Findings on computed tomography and single photon emission tomography mirrored the areas of dysfunction suggested by the neuropsychological profiles and demonstrated abnormalities restricted to the left hemisphere or involving bilateral frontotemporal cortices.Brains of 3 patients,with distinctive clinical pictures,have been examined at autopsy.Each revealed a focal distribution of atrophy,gliosis and spongiform change,and an absence of senile plaques and neurofibrillary tangles.There was clinical and pathological overlap with frontal lobe dementia.We argue that progressive language disorder is clinically heterogenous and forms part of a spectrum of clinical presentations of non-Alzheimer lobar atrophy.
 
Related Tags
(click to filter results - removes previous filter)

agnosia
anomic aphasia
aphasia
aphasia,progressive
aphasia,progressive,primary
CAT scan
CAT scan,abnormal
cerebral cortical atrophy
familial
genetic neurologic disorders
language disorder in adults
lobar atrophy
mutism
neuropathology
neuropathology,brain
personality change
single photon emission computed tomography
spongy degeneration of brain

Click Here to return To Results