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Adverse Events Following Pertussis and Rubella Vaccines, Summary of a Report of the Institute of Medicine
JAMA 267:392-396, Howson,C.P.&Fineberg,H.V., 1992
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Article Abstract
The committee found the available evidence weaker but still consistent with a causal relation between DTP vaccine and two conditions-acute encephalopathy and hypotonic,hyporesponsive episodes-and between rubella vaccine and chronic arthritis in adult women.Estimated incidence rates of these adverse events following vaccination are provided,where possible.The committee found that the evidence does not indicate a causal relation between DTP vaccine and infantile spasms,hypsarrhythmia,Reye's syndrome, and sudden infant death syndrome.The committee found insufficient evidence to indicate either the presence or absence of a causal relation between DTP vaccine and chronic neurologic damage,aseptic meningitis,erythema multiforme or other rash,Guillain-Barre syndrome,hemolytic anemia,juvenile diabetes,learning disabilities and attention-deficit disorder,peripheral mononeuropathy,or thrombocytopenia,and between rubella vaccine and radiculoneuritis and other neuropathies or thrombocytopenic purpura.The committee's evaluative methods are briefly described and a summary of research needs is provided.
 
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adverse drug reaction
diphtheria-tetanus-pertussis immunization
encephalitis
encephalomyelitis
encephalopathy
hypotonia
hypotonia,infants
pertussis immunization
rubella vaccine
vaccination,neurologic complications with

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