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The committee found the available evidence weaker but still consistent with a causal relation between DTP vaccine and two conditions-acute encephalopathy and hypotonic,hyporesponsive episodes-and between rubella vaccine and chronic arthritis in adult women.Estimated incidence rates of these adverse events following vaccination are provided,where possible.The committee found that the evidence does not indicate a causal relation between DTP vaccine and infantile spasms,hypsarrhythmia,Reye's syndrome, and sudden infant death syndrome.The committee found insufficient evidence to indicate either the presence or absence of a causal relation between DTP vaccine and chronic neurologic damage,aseptic meningitis,erythema multiforme or other rash,Guillain-Barre syndrome,hemolytic anemia,juvenile diabetes,learning disabilities and attention-deficit disorder,peripheral mononeuropathy,or thrombocytopenia,and between rubella vaccine and radiculoneuritis and other neuropathies or thrombocytopenic purpura.The committee's evaluative methods are briefly described and a summary of research needs is provided. |
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