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A Chronic Illness of Fatigue, Neurologic and Immunologic Disorders, & Active Human Herpesvirus Type 6 Infection
Ann Int Med 116:103-113, Buchwald,D.,et al, 1992
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Article Abstract
Neurologic symptoms,MRI findings,and lymphocyte phenotyping studies suggest that the patients may have been experiencing a chronic, immunologically mediated inflammatory process of the central nervous system.The active replication of HHV-6 most likely represents reactivation of latent infection,perhaps due to immunologic dysfunction.Our study did not directly address whether HHV-6,a lymphotropic and gliotropic virus, plays a role in producing the symptoms or the immunologic and neurologic dysfunction seen in this illness.Whether the findings in our patients,who came from a relatively small geographic area,will be generalizable to other patients with a similar syndrome remains to be seen.
 
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chronic fatigue syndrome
concentration,impaired
disability,neurological
fatigue
headache
herpes virus
herpes virus infection
human herpesvirus 6
immunologic disease
lymphadenopathy
MRI
MRI,abnormal
muscle pain
neurologic signs
neurologic symptoms
postviral fatigue syndrome
respiratory tract infection
seizure
transient neurologic deficit
viral infection

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