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Antiepileptic drugs,especially carbamazepine and phenytoin,are potent liver enzyme inducers.Since praziquantel,the drug used to treat neurocysticercosis,undergoes extensive liver first-pass metabolism,we carried out a prospective study to verify whether there was a decrease in oral bioavailability induced by carbamazepine and phenytoin.Carbamazepine and phenytoin significantly decreased concentrations of praziquantel,due to increased clearance secondary to induction of first pass-liver metabolism The magnitude of the decrease is surprisingly high and may be responsible for failures of treatment. |
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