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Chronic Neurodegenerative Disease Associated with HTLV-II Infection
Lancet 339:645-646, Hjelle,B.,et al, 1992
See this aricle in Pubmed

Article Abstract
Although human T-cell leukaemia virus(HTLV)type I is known to cause a number of diseases,there has been no convincing evidence of pathological changes after infection with the related virus,HTLV-II.We have found an endemic focus of HTLV-II infection among members of an American Indian population in New Mexico,USA.We set out to determine the pathological consequences of HTLV-II infection in this population and identified two sisters(aged 59 and 46 years)with a disease superficially resembling the myeloneuropathy induced by HTLV-I.These women had a syndrome similar to the olivopontocerebellar atrophy variant of multiple system atrophy,and HTLV-II infection was confirmed by western blot and the polymerase chain reaction.Thus,HTLV-II may,like HTLV-I,cause a progression neurodegenerative disease.
 
Related Tags
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cerebellar atrophy,primary
cerebellar degeneration
degenerative diseases of CNS
falling
familial
gait disorder
human T-lymphotropic virus type II(HTLV-II)
myelopathy
Native Americans
paraparesis
paraparesis,spastic
polymerase chain reaction
Western immunoblot test

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