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Reversal of a Neurologic Paraneoplastic Syndrome with Octreotide (Sandostatin) in a Pt with Glucagonoma
Am J Med 91:434-436, Holmes,A.,et al, 1991
See this aricle in Pubmed

Article Abstract
A 69-year-old woman with classic glucagonoma syndrome had associated progressive neurologic disease manifest as dementia,ataxia,optic atrophy, and lower limb weakness.Visual evoked responses(VERs)were absent bilaterally.After an attempt at resection was unsuccessful,therapy was started with somatostatin analogue(Sandostatin,SMS 201-995).Over the ensuing 3 months,there was a decrease in the plasma glucagon level, resolution of the rash,weight gain,reversal of the dementia,and an improvement in coordination and limb weakness.Subsequent VERs revealed bilaterally delayed responses.
 
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ataxia
carcinoma of pancreas
dementia
dementia,reversible
dementia,treatment of
encephalomyelitis
glucagonoma
leg weakness,bilateral
octreotide
optic atrophy
optic neuropathy
paraparesis
remote effect of cancer on the nervous system
spasticity
treatment of neurologic disorder
visual acuity,decreased
visual evoked response
weakness

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