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Low-Dose Trimethoprim-Sulfamethoxazole Prophylaxis for Toxoplasmic Encephalitis in Patients with AIDS Ann Int Med 117:106-111, 163-1641992., Carr,A.,et al, 1992 See this aricle in Pubmed Article Abstract No patient ion the trimethoprim-sulfamethoxazole group and no patient seronegative for Toxoplasma gondii developed toxoplasmic encephalitis, compared with 12 of 36(33%;95%Cl,19%to 51%)seropositive patients in the pentamidine group(trimethoprim-sulfamethodixazole compared with pentamidine,P=0.008).A significant difference was seen in the time of toxoplasmic encephalitis between the trimethoprim-sulfamethoxazole group (no case at 1150 days)and the pentamidine group(median time 460 days)(P=0. 004).Neither the CD4=lymphocyte count at the start of prophylaxis nor zidovudine therapy during the period of prophylaxis influenced the rate of toxoplasmic encephalitis in any group.Low-dose trimethoprim- sulfamethoxazole(four tablets per week)appears to be effective prophylaxis against toxoplasmic encephalitis in HIV infected patients with previous P. carinii pneumonia.A prospective,randomized,controlled study is needed to further evaluate these findings.

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(click to filter results - removes previous filter) acquired immunodeficiency syndrome adverse drug reaction human immunodeficiency virus type 1 meningoencephalitis,toxoplasma opportunistic infection opportunistic infection,CNS pneumocystis carinii prevention of neurologic disorders toxoplasmosis,CNS toxoplasmosis,prophylaxis treatment of neurologic disorder trimethoprim-sulfamethoxazole

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