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Release of Superoxide Dismutase Into CSF as a Marker of Brain Lesion in Acute Cerebral Infarction
Stroke 23:515-518, Strand,T.&Marklund,S.L., 1992
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Article Abstract
Evaluation of biochemical patterns in cerebrospinal fluid may add diagnostic and prognostic information.We tested to determine whether the concentration of superoxide dismutase in cerebrospinal fluid is a marker of brain tissue damage in acute ischemic stroke.Methods:We investigated 36 acute ischemic stroke patients for cerebrospinal fluid activity of the enzyme superozide dismutase on two occasions shortly after symptom onset (average,day 1 and day 4).Results:In 75%of the patients,the first of two lumbar punctures revealed the maximal superoxide dismutase value.The amount in the cerebrospinal fluid was significantly correlated with the size of infarction on computed tomographic scan(p<0.001 by analysis of variance)and to functional impairment and stroke-related mortality during initial hospital stay(p(0.002).The correlation of initial superoxide dismutase concentration with the need for long-term institutional care and mortality at 3 months after the stroke was also significant(p<0.03). Conclusions:We conclude that superoxide dismutase in cerebrospinal fluid is a marker of an acute brain lesion and has some value as a prognostic predictor.This small enzyme leaks rapidly from ischemically injured cells.
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cerebrospinal fluid
cerebrospinal fluid,abnormal
cerebrospinal fluid,enzymes in
cerebrovascular accident
superoxide dismutase
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