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Twenty patients were treated at three hospitals in 13 months.Three doses were tested:0.6 mg/kg(n=8),0.85 mg/kg(n=6),and 0.95 mg/kg(n=6).Two patients,one each at the two highest doses,sustained fatal intracerebral hemorrhages.Three patients(15%)improved by>/=4 points on the National Institutes of Health Stroke Scale by 24 hours.Conclusions:These observations suggest that tissue plasminogen activator treatment of acute ischemic stroke 91-180 minutes from onset in doses of./=0.85 mg/kg is attended by a risk of intracerebral hemorrhage approximating 17%(range 3- 44%,95%confidence interval).The rate of early neurological improvement observed in this study was small but does not exclude an improvement over the natural history.Future study with placebo control subjects and stratification by time to treatment if indicated. |
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adverse drug reaction
CAT scan
CAT scan,abnormal
cerebrovascular accident
cerebrovascular accident,acute management of
cerebrovascular accident,thrombolytic agents in treatment
fibrinolytic agents
fibrinolytic agents,complications
intracerebral hemorrhage
tissue plasminogen activator,intravenous
treatment of neurologic disorder
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