[home]
[thesaurus]
Click Here to return To Results
Urgent Therapy for Stroke Part I, Pilot Study of Tissue Plasminogen Activator Administered within 90 Minutes
Stroke 23:632-640, Brott,T.G.,et al, 1992
See this aricle in Pubmed
Article Abstract
Seventy-four patients were treated within 90 minute of symptom onset over seven dose tiers of tissue plasminogen activator,ranging from 0.35 mg/kg to 1.08 mg/kg.Intracranial hematoma with associated neurological deterioration occurred in three patients and was related to increasing doses of tissue plasminogen activator(p=0.045).Intracranial hematoma did not occur in any of the 58 patients treated with=0.85 mg/kg.Major neurological improvement occurred in 22 patients(30%)at 2 hours from the initiation of tissue plasminogen activator and in a total of 34 patients (46%)at 24 hours,but major neurological improvement was not related to increasing doses of tissue plasminogen activator or to stroke type. Conclusions:Patients with acute stroke can be evaluated and treated within 90 minutes.Tissue plasminogen activator for acute ischemic infarction is not without risk,but the potential for clinical benefit justifies a randomized clinical trial.To date,differences in hemorrhagic risk or neurological benefit of tissue plasminogen activator for particular ischemic stroke types are not apparent.
Related Tags
(click to filter results - removes previous filter)
adverse drug reaction
cerebrovascular accident
cerebrovascular accident,acute management of
cerebrovascular accident,thrombolytic agents in treatment
cerebrovascular accident,time of presentation
fibrinolytic agents
fibrinolytic agents,complications
tissue plasminogen activator,intravenous
treatment of neurologic disorder
Click Here to return To Results