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In the group of patients treated with prothrombin complex concentrate,the mean prothrombin time decreased from 2.83 to 1.22 International Normalized Ratio within 4.8 hours,compared with a decrease from 2.97 to 1.74 within 7.3 hours in those given fresh-frozen plasma(i.e.,four to five times more rapidly after treatment with prothrombin complex concentrate)(p<0.001). Symptoms and signs of intracerebral hemorrhage,measured on an eight-graded Reaction Level Scale,progressed on average 0.2 grades in patients given prothrombin complex concentrate compared with 1.9 grades in those given fresh-frozen plasma(p<0.05).In patients with prothrombin values above 1. 46,clinical progression within 12 hours occurred in five of six cases. Treatment with prothrombin complex concentrate reverses coagulation more rapidly that fresh-frozen plasma,which might be importance for the prevention of further bleeding. |
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