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A Familial Disorder with Subcortical Ischemic Strokes, Dementia, and Leukoencephalopathy Neurol 42:1015-1019, Mas,J.L.,et al, 1992 See this aricle in Pubmed Article Abstract A family had a disorder characterized by(1)a pattern suggestive of autosomal dominant inheritance,(2)recurrent attacks of focal brain deficits starting in midadulthood and often leading to severe motor disability with pseudobulbar palsy and dementia of the subcortical type and(30 neuroimaging evidence of leukoencephalopathy and well-circumscibed lesions consistent with small deep infarcts.Some affected members were clinically asymptomatic by had MRI signs of leukoencephalopathy.Extensive investigations failed to uncover a previously described recognizable genetic disorder.

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(click to filter results - removes previous filter) arteriopathy cerebrovascular accident cerebrovascular accident,familial occurrence cerebrovascular accident,multiple cerebrovascular accident,recurrent dementia dementia,cerebrovascular disease causing familial genetic neurologic disorders leukoencephalopathy MRI MRI,abnormal pseudobulbar palsy

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