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Ergot alkaloid preparations such as ergotamine(Cafergot,Sandoz,East Hanover,New Jersey)and methysergide(Sansert,Sandoz)are used to treat migraine headache.Characteristic histologic changes are seen in patients with methysergide-induced valvular disease(primarily mitral and aortic regurgitation)(1,2).Recently,ergotamine-induced valvular disease was documented pathologically(3).We report the echocardiographic and pathologic features of five patients with valvular disease associated with long-term ingestion of ergot alkaloids. |
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