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Central Nervous System Disease in Patients with Systemic Lupus Erythematosus
Neurol 42:1649-1657, Futrell,N.,et al, 1992
See this aricle in Pubmed

Article Abstract
Central nervous system(CNS)dysfunction in patients with systemic lupus erytematosus(SLE)is highly variable,although it is often described under a single heading of"neuropsychiatric"or"CNS"SLE.To clarify these CNS abnormalities,we studied 91 lupus patinets,63 of whom had CNS symptoms or signs,over 599 patient years.By placing patients in relatively homogeneous clinical groups(stroke,seizure,suicide attempt,hallucination,confusion, decreased alertness)we detected significant(but variable among groups) correlations with other manifestations of SLE,suggesting separate mechanisms for each CNS disorder.These correlations were lost if all"CNS- SLE"was considered as a single group.Patients with decresed alterness often had undetected systemic infections and had a high death rate from infection,rather than from CNS-SLE.The understanding of the pathogenesis and potential treatment of CNS disorders in lupus will depend on classifying the patients into homogeneous groups.
 
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bacterial infection
central nervous system,infection of
cerebrovascular accident
confusion
fungal infection,CNS
hallucination
level of consciousness,decreased
mortality
neurologic signs
pneumonia
review article
seizure
suicide
systemic lupus erythematosus
systemic lupus erythematosus,neurologic complications with
treatment of neurologic disorder

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