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A Prospective Study of Cognitive Funct Following Low-Dose Cranial Radiation for Bone Marrow Trnsplant Pediatrics 90:447-450, Kramer,J.H.,et al, 1992 See this aricle in Pubmed Article Abstract This study prospectively examined the effects of low doses of cranial irradiation on psychological development in children.The subjects were 22 children receiving bone marrow transplantation.Fifteen children receiving cranial doses ranging from 350 to 1200 cGy as part of their conditioning regimen were contrasted to seven children who were not radiated.Measures of intellectual and psychological development were administered to all subjects prior to transplant and again at one-year follow-up,regardless of the dose of cranial radiation received or the age at which radiation was administered.In addition,there were no significant cores relative to baseline in a smaller cohort of children followed up for 3 years.Although no significant between-group findings were found,examination of individual cases revealed a high degree of variability,with decrements in IQ of 10 points or more found in seven children at the one year follow-up.Findings suggest that doses less than 1500 cGy may prove to be relatively well tolerated with respect to long-term cognitive and psychological development,even in young children,although caution is urged in light of the limited length of follow-up.

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