|
|
|
|
The gap between the end of the visual aura and headache onset in classical migraine has been called the free interval.In a retrospective study of twenty-five migraineurs who had noted a gap,only three reported feeling normal at that time:twenty-two described alterations in mood,detachment from the environment or other people,fears,disturbances of speech or thought,or somatic symptoms.The interval lasted less than an hour in seventeen of the twenty-two but in five persisted for 1 to 5 hours.These symptoms suggest involvement of the frontal and temporal cortices as well as the hypothalamus;they do not conform to Leao's spreading depression or a vascular mechanism,but are in keeping with a diffuse cerebral process with focal manifestations. |
|