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Levodopa-Nonresponsive Lewy Body Parkinsonism:Clinicopathologic Study of Two Cases Neurol 42:1323-1327, Mark,M.H.,et al, 1992 See this aricle in Pubmed Article Abstract We report two patients with a primarily akinetic form of parkinsonism who were nonresponsive to treatment with levodopa.At autopsy,both patients had many Lewy bodies in brainstem and diencephalic nuclei,with sparse Lewy bodies in association cortices and more numerous Lewy bodies in the limbic cortices,consistent with the transitional form of Lewy body disease.These cases emphasize that(1)Lewy body Parkinson's disease cannot be excluded on the basis of atypical presentation or levodopa nonresponsiveness,and(2)the clinicopathologic spectrum of Lewy body disease is varied.

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(click to filter results - removes previous filter) bradykinesia dementia L-dopa neuropathology neuropathology,brain Parkinson disease Parkinson disease,akinetic form Parkinson disease,diagnosis Parkinson disease,heterogeneity of Parkinson disease,L-dopa nonresponsive sinemet treatment of neurologic disorder

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