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The Efficacy & Safety of Ticlopidine & Aspirin in Non-Whites:Subgroup from Ticlopidine Aspirin Stroke Study
Neurol 43:27-31, Weisberg,L.A., 1993
See this aricle in Pubmed

Article Abstract
We analyzed the efficacy of ticlopidine and aspirin in the non-white subgroup of patients from the Ticlopidine Aspirin Stroke Study.In this double-blind,randomized,multicenter study,patients received either ticlopidine 250 mg(312 non-white patients)or aspirin 650 mg(291 non-white patients)twice a day.The 1-year cumulative event rate per 100 patients for nonfatal stroke or death from any cause was 5.5 for ticlopidine and 10.6 for aspirin-An apparent 48.1%reduction in risk with ticlopidine relative to aspirin.The 1-year cumulative event rate for fatal or non-fatal stroke was 3.7 for ticlopidine and 9.4 for aspirin-an apparent 60.8%reduction in risk with ticlopidine relative to aspirin.The cumulative event rates for both endpoints also were lower in ticlopidine-treated patients after the 2nd and 3rd years.These reductions were not significantly different between treatment groups,but were of the same order of magnitude as previously found for the total series,which did attain statistical significance(p=0.048),and the frequency of adverse events was not significantly different between the two treatment groups.Severe neutropenia,the most serious adverse event associated with ticlopidine use,did not occur in non-white patients.These results suggest that ticlopidine is superior to aspirin for stroke prevention in non-whites.
 
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adverse drug reaction
aspirin
blacks
cerebrovascular accident,prevention of
cerebrovascular accident,racial differences
neutropenia
platelet inhibiting drugs
ticlopidine

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