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Three-and Four-Year Cognitive Outcome in Children with Noncortical Brain Tumors & Whole-Brain RT Ann Neurol 32:551-554, Radcliffe,J.,et al, 1992 See this aricle in Pubmed Article Abstract Cognitive function and school achievement were studied prospectively over 3 to 4 years in 19 children treated for brain tumors with whole-brain radiotherapy;14 of 19 also received adjuvant chemotherapy.For the group as a whole,mean IQ fell from a baseline of 104 to 92 at follow-up(p<0.01).Age was inversely correlated with change in IQ over time(r=0.71;p<0.001). Children younger than 7 years at diagnosis had a mean IQ loss of 27 points,while children over 7 years at diagnosis showed no significant decrease in IQ.Decline in IQ occurred between baseline and year 2 of follow-up;none could be documented between years 2 and 4.All children younger than 7 years at diagnosis were receiving special education at follow-up;50%of the children over 7 years at diagnosis were receiving supplemental educational services.

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