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Six of 110 patients(5.5%)with forms of motor neuron disease had abnormal titers of GM1 antibodies of 1:1,600 or higher.Four others came with previously known high titers.Three patients with upper motor neuron(UMN) signs had titers of 1,600;those with probable or no UMN signs had higher titers.Nine patients had conduction block;six of them had abnormal antibody titers,four with 6,400 or higher.Therefore,patients with motor neuron disease and abnormal anti-GM1 titers may have UMN signs or conduction block. |
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