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Paraneoplastic Cerebellar Degener I A Clinical Analysis of 55 Anti-Yo Antibody-Positive Pts
Neurol 42:1931-1937, Peterson,K.,et al, 1992
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Article Abstract
We reviewed the clinical findings in 55 patients with cerebellar degeneration associated with the anti-Yo antibody(an anti-Purkinje cell antibody identified in this study by histochemistry and Western blot).The patients were all women,26 to 85 years old.Fifty-two of them proved to have malignancies,almost exclusively breast or gynecologic cancers and usually confined to the involved organs and local lymph nodes.One woman had adenocarcinoma of the lung,and in three no malignancy has yet been identified.In 34 of 52 patients with cancer,the neurologic syndrome preceded the diagnosis of cancer and in many led to that diagnosis. Patients subacutely developed a pancerebellar disorder that was substantially disabling in most,with 37 of 48 assessable patients being unable to walk or sit unassisted.Laboratory evaluation revealed lymphocytic pleocytosis in 35 patients,with eventual cerebellar atrophy on imaging studies in seventeen.The disabling neurologic syndrome generally did not respond to treatment,but the cancer was often successfully treated.The presence of the anti0Yo antibody in aptients with cerebellar symptoms warrants an aggressive approach to diagnosis and treatment of the underlying cancer,and many are curable at the time neurologic symptoms develop.
 
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anti Yo antibody
ataxia
ataxic gait
autoantibodies
carcinoma
carcinoma of breast
carcinoma of ovary
cerebellar degeneration
cerebrospinal fluid
cerebrospinal fluid,abnormal
gait disorder
neurologic signs
nystagmus
paraneoplastic cerebellar degeneration
Purkinje cell
remote effect of cancer on the nervous system
review article

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