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We describe three patients with known or suspected small-cell lung cancer (SCLC),paraneoplastic neurological syndromes,and antineuronal antibodies who had usually benign clinical courses.One patient survived 8 years free of disease and one was positive for the anti-Hu antibody.A second patient survived 6 years after spontaneous tumour regression and had an atypical antineuronal antibody.A third patient with both the anti-Hu and atypical antineuronal antibody had spontaneous regression of a lung mass.All three patients had a subacute sensory neuropathy.Since paraneoplastic antineuronal antibodies also bind to tumour cells,these cases suggest that some(paraneoplastic)neurological syndromes without identifiable tumour may result from immune-mediated eradication of tumour cells. |
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