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Results of nerve conduction studies,electronystagmographic recording,and magnetic resonance imaging in patients with LOFA closely corresponded to observations made in patients with FRDA.In addition,genetic linkage analysis using markers tightly linked to the FRDA locus on chromosome 9 showed that all affected members of the LOFA family,but not their unaffected siblings,had inherited identical paternal and maternal genotypes.Data suggest that LOFA may also result from mutation within the FRDA locus. |
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