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Botulinum Antibodies in Dystonic Patients Treated with Type A Botulinum Toxin Neurol 43:1715-1718, Zuber,M.,et al, 1993 See this aricle in Pubmed Article Abstract We measured serum antibodies to botulinum toxin(ABT)in 96 patients with focal dystonia who had been treated with type A botulinum toxin.The frequency of detectable ABT was 3%(three patients).Patients with ABT had received more than 50 mg of botulinum toxin,and the shortest time between two injections was significantly less than in patients without ABT.The clinical evolution of the three patients was heterogeneous:one had decreased effectiveness with repeated injections,another had persistent improvement,and the third never responded to toxin injections.

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