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Analysis of Dystrophin Expression after Activation of Myogenesis in Amniocytes, Chorionic-Villus Cells, and Fibroblasts
NEJM 329:915-920, Sancho,S.,et al, 1993
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Article Abstract
We found that 60 of 61 myotube cultures from subjects with no family history of Duchenne's dystrophy expressed dystrophin.Both myotube cultures from the two patients with Becker's dystrophy also expressed dystrophin, but all cultures from nine patients and two fetuses with Duchenne's dystrophy were dystrophin-deficient.
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dystrophin
genetic diagnosis,prenatal
muscular dystrophy
muscular dystrophy,Duchenne
muscular dystrophy,Duchenne,neonatal screening
neurologic disease,diagnoses of
prenatal diagnosis by amniocentesis
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