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We studied 10 regular exercising men with Parkinson's disease on levodopa (LD)under two conditions-no exercise and vigorous exercise started 1 hour after LD ingestion.We compared LD levels and motor scores on the Unified Parkinson's Disease Rating Scale(UPDRS).There was a high degree of agreement between plasma LD level and the patients'UPDRS scores 30 minutes later(mean Eta2=0.84)in both conditions,with no difference between the two.We conclude that LD levels accurately reflect UPDRS motor function in these patients,and that vigorous exercise started 1 hour after LD ingestion does not influence LD or motor scores. |
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