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Early Childhood Prolonged Febrile Convulsions, Atrophy & Sclerosis of Mesial Struc & Temporal Lobe Epilepsy:An MRI Study Neurol 43:1083-1087, Cendes,F.,et al, 1993 See this aricle in Pubmed Article Abstract We performed MRI volumetric measurements of the amygdala(AM)and hippocampal formation(HF)in a group of 43 patients with temporal lobe epilepsy not controlled by optimal drug treatment.Fifteen patients(35%)had a history of prolonged febrile convulsions(PFC)in early childhood;30 patients underwent surgery,and histopathology was available in twenty- four.The mean values of AM and HF volumes ipsilateral to the EEG focus were significantly smaller than those of normal controls.The volumetric measurements showed a more pronounced atrophy of the AM in patients with a history of PFC,although the HF volumes were also smaller in this group. Patients with a history of PFC had a higher proportion of more severe mesial temporal sclerosis(MTS)compared with those with no PFC.These findings confirm a correlation between early childhood PFC,the severity of atrophy of mesial structures,and MTS.

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(click to filter results - removes previous filter) lobar atrophy mesial temporal sclerosis MRI MRI,abnormal risk factors seizure seizure,febrile seizure,febrile,risk of epilepsy following seizure,focus seizure,psychomotor-temporal lobe

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