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Carbonic anhydrase inhibitors can cause nephrolithiasis.We studied 20 patients receiving long-term carbonic anhydrase inhibitor treatment for periodic paralysis and myotonia.Three patients on acetazolamide(15%) developed renal calculi.Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in another,permitting continued treatment.Renal function remained normal in all patients.Nephrolithiasis is a complication of acetazolamide but does not preclude its use. |
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