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An encephalopathy characterized by confusion,stupor,and mutism frequently occurs during administration of the chemotherapeutic drug ifosfamide(IFX). We investigated two patients who developed encephalopathy during IFX infusion.Both exhibited a rapid and near-complete restoration of baseline mental status functioning concurrent with EEG improvement after administration of intravenous diazepam.We recommend an EEG and trial of benzodiazepines in patients with IFX encephalopathy. |
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