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The effects of aspartame(L-aspartyl-L-phenylalanine methyl ester;APM on the neurological status of children with well-documented seizures were examined in a randomized,double-blind,placebo-controlled,crossover study. There were no significant differences between APM and placebo in the standard EEG or 24-hour EEG.No differences were noted for the STESS or the Conners ratings,and no differences were noted for any of the biochemical measures(except for expected increases in phenylalanine and tyrosine after APM).Our findings indicate that,in this group of vulnerable children,APM does not provoke seizures. |
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