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Trimethyltin Encephalopathy
Arch Neurol 50:1320-1324, Feldman,R.G.,et al, 1993
See this aricle in Pubmed

Article Abstract
A chemistry student was acutely exposed to vapors of an organotin compound.Seventy-two hours later,he exhibited delirium,spatial disorientation,perseveration,inappropriate affect and memory deficits.Five months later,he experienced episodes of complex partial seizures,which continue to require anticonvulsant medication after seven years. Trimethyltin was identified in blood and urine samples taken 17 days after the accident;the blood level of trimethyltin was elevated 35 days after exposure.Serial electroencephalograms showed persistent left temporal paroxysmal epileptogenic potentials.Serial neuropsychological tests revealed persistent memory defects,cognitive dysfunction,and dysphoria 4 years after exposure.We review acute,resolving,and long term residual neurotoxic effects of trimethyltin in man.We describe detailed clinical observations,serial neuropsychological test results, electroencephalographic findings,and exposure data in this patient, confirming the limbic system effects of trimethyltin and relating them to the known histopathologic pattern of this condition.
 
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confusion
disorientation
electroencephalogram
electroencephalogram,abnormalities of
encephalopathy
limbic system
memory,impairment of
neurotoxin
psychological testing
seizure
toxic encephalopathy
toxins,nervous system
trimethyltin

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