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All patients reported substantially decreased pain promptly after treatment,with maximum relief at 20 to 30 minutes and lasting 2 to 4 hours.Patients gradually decreased the use of aspirin in chloroform as pain abated.Topical aspirin dissolved in chloroform is an effective means of reducing pain due to herpes zoster and postherpetic neuralgia in most patient.The locus of pain origin and analgesia induced by topical aspirin is most likely at cutaneous free-nerve ending pain receptors.The mechanism responsible for the analgesic properties of aspirin is probably not the same as that responsible for its anti-inflammatory properties. |
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