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We studied the effects of intravenous immunoglobulin(IVIg)in 12 patients with motor neuron syndromes associated with high titers of anti-GM1 antibodies.Five of the patients had conduction blocks.The study design was a double-blind,placebo-controlled,crossover trial with IVIg(0.4 g/kg body weight per day injected for 5 consecutive days).We evaluated the patients before and 5,28,and 56 days after drug administration using a computerized analyzer for muscle strength,the Norris scale for disability,motor nerve conduction velocities for patients with conduction blocks,and measurements of immunologic markers.Compared with placebo,IVIg induced a significant increase in muscle strength only in the patients with conduction blocks. |
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