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Surfactant Therapy and Intracranial Hemorrhage:Review of the Literature and Results of New Analyses Pediatrics 92:775-786, Gunkel,J.H.&Banks,P.L.C., 1993 See this aricle in Pubmed Article Abstract During the controlled studies with beractant,treated newborns of 600 to 750 g birth weight were at higher risk for grades I and II intracranial hemorrhage than control newborns.There was no increased risk for grades III and IV hemorrhage among these newborns,nor was there increased risk of hemorrhage among any other patient groups.This finding did not result in increased morbidity for the affected patients;at 2 years adjusted age,they were not different from the control infants of 600 to 750 g birth weight. Retrospective examination of the database could not pinpoint the mechanism behind the finding,but it might have been related to changes in cerebral blood flow after surfactant uncompensated by ventilator management of oxygenation and ventilation.Surfactant therapy may set in motion hemodynamic changes that6 could predispose to intracranial hemorrhage in certain circumstances,but this can probably be compensated by careful management of oxygenation and ventilation.A relationship between surfactant therapy and intracranial hemorrhage is probably not isolated to any particular surfactant preparation or method of delivery;studies comparing surfactants have shown to differences in rates of intracranial hemorrhage.

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(click to filter results - removes previous filter) adverse drug reaction beractant hemorrhage,intracranial,newborn iatrogenic neurologic disorders intracranial hemorrhage low birth weight premature infant premature infant,problems in respiratory distress syndrome,neurologic status with review article surfactant

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