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Children exposed to phenytoin in utero had a mean(+/-SD)global IQ 10 points lower(95%confidence interval,4.9 to 15.8 points)than their matched controls(113.4+/-13.1 and 103.3+/-25.1;P=.038).The Reynell language development scores followed a similar trend,with children exposed to phenytoin scoring significantly lower than their controls.Phenytoin- exposed children had a global IQ of 84 or less significantly more often than the control group(P<.01).Children exposed in utero to carbamazepine did not differ from their controls on any of the neurobehavioral tests.Our study suggests a clinically important negative effect of phenytoin on neurobehavioral development,independent of maternal or environmental factors,causing a substantial number of children to achieve a lower score than expected on cognitive tests.No similar effects could be shown after gestational use of carbamazepine. |
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adverse drug reaction anticonvulsants,cognitive function with anticonvulsants,untoward effects of carbamazepine congenital malformation,dilantin therapy causing developmental evaluation dilantin dilantin,toxicity intelligence quotient intelligence testing in children intrauterine pregnancy,neurologic complications in psychological testing psychological testing,children
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