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Carbamazepine Toxicity Resulting from Generic Substitution Neurol 43:2696-2697, 24351993., Gilman,J.T.,et al, 1993 See this aricle in Pubmed Article Abstract Generic substitution is practiced widely in both hospital and community settings.There have been several reports of reduced serum concentrations and seizure exacerbation following generic substitution of Tegretol.We describe the first 2 cases of carbamazepine toxicity resulting from the substitution of Tegretol with Epitol.Two 6-year-old children experienced increases in the maximum serum carbamazepine concentration,one of 22%and one of 41%.Both became asymptomatic when their serum concentrations were lowered and had no residual effects.

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(click to filter results - removes previous filter) adverse drug reaction anticonvulsants,bioavailability anticonvulsants,blood level determination of anticonvulsants,untoward effects of carbamazepine carbamazepine,toxicity generic drugs

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