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The symptoms of Alzheimer's disease are associated with pathological change and loss of neurons in the medial temporal lobe,By yearly temporal- lobe-oriented computed tomograms the average rate of atrophy of the medial temporal lobe was 15.1%per year(95%CI 10-0,20-l)in 20 patients with histopathologically,confirmed Alzheimer's disease and 1-5%(0-2,2-8)in 47 healthy ageing controls.Such excessive atrophy presumably reflects the vulnerability of the medial temporal lobe to a catastrophic event,probably a pathological cascade process.Thus,Alzheimer's disease may not be due simply to an acceleration of normal ageing but,rather,is the consequence of a true disease process. |
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